Novavax vaccine is highly protective against COVID-19 in Phase 3 results

Contact: Will Sansom, 210-567-2579, sansom@uthscsa.edu

Elizabeth Allen, 210-358-2344, elizabeth.allen@uhs-sa.com

SAN ANTONIO (June 14, 2021) — Researchers at UT Health San Antonio are buoyed by today’s news that the Novavax vaccine is strongly effective against the COVID-19 virus. Biotechnology company Novavax released Phase 3 clinical trial results from 119 sites in the U.S. and Mexico this morning (June 14).

UT Health San Antonio collaborated with University Health as part of the international COVID-19 Prevention Network and enrolled 176 Novavax clinical trial participants in San Antonio for the Phase 3 study, which is called PREVENT-19.

“We are so excited that UT Health San Antonio, University Health and our city played a part in this important trial,” said site principal investigator Barbara Taylor, MD, MS, associate professor of infectious diseases at UT Health San Antonio and assistant dean for the MD/MPH program diseases in the university’s Joe R. and Teresa Lozano Long School of Medicine.

“We want to say a huge thank you to our participants for their continued commitment to helping our community end COVID-19,” Dr. Taylor said.

The vaccine candidate, called NVX-CoV2373, is a protein engineered from the genetic sequence of the SARS-CoV-2 virus that causes COVID-19. The vaccine candidate was shown to have a reassuring safety profile and elicited a strong immune response in a Phase I trial in results announced by the company last August.

Because Novavax is a different type of vaccine than the Pfizer, Moderna and Johnson & Johnson vaccines, it promises to be an important solution worldwide.

“The Novavax vaccine is a protein adjuvant vaccine and the first COVID-19 vaccine using that strategy to show efficacy,” Dr. Taylor said. “This is important because it is stable in a standard refrigerator and can be used in locations where having a minus-80 degree freezer, required by some of the other vaccines, is a challenge: pharmacies, primary care clinics, rural settings, and low- and middle-income countries. This can be yet another tool to help address equity in vaccine access.”

Dr. Taylor said the local research team is particularly happy to see:

  • 100% protection against moderate or severe COVID-19 disease.
  • high efficacy in high-risk populations, including those over 65 years of age.
  • high efficacy against variants of concern.

“We look forward to data from the study being published and an anticipated Emergency Use Authorization submission in the next few months,” Dr. Taylor said.

The Novavax vaccine is administered in two doses timed at least three weeks apart.


The University of Texas Health Science Center at San Antonio, also referred to as UT Health San Antonio, is one of the country’s leading health sciences universities and is designated as a Hispanic-Serving Institution by the U.S. Department of Education. With missions of teaching, research, patient care and community engagement, its schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have graduated 39,700 alumni who are leading change, advancing their fields, and renewing hope for patients and their families throughout South Texas and the world. To learn about the many ways “We make lives better®,” visit http://www.uthscsa.edu.

About University Health System, now referred to as University Health

University Health System, now referred to as University Health, is San Antonio’s only locally owned health system and the only academic medical center in South Texas. Its University Hospital serves as the region’s Level I trauma center for adults and children, and is the only area hospital to be state-designated at the highest level for both its Maternity Center and Neonatal Intensive Care Unit. Outpatient care is provided through a comprehensive network of urgent, primary and specialty care centers. For more than 100 years, University Health has been committed to delivering compassionate, culturally competent and high-quality healthcare, based on a strong foundation of outcomes‐based research and innovative teaching. Learn more at UniversityHealthSystem.com. Follow us on Twitter and Facebook.



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