UT Health San Antonio physiatrist helps write first American Diabetes Association guidelines to include disability management

A clinician and researcher with The University of Texas Health Science Center at San Antonio helped “write the book” when it comes to standards of care for diabetes.

Monica Verduzco-Gutierrez, MD, professor and chair in the Department of Physical Medicine and Rehabilitation, contributed a section of the latest American Diabetes Association Standards of Care guide.

Under her guidance, a portion was added to the ADA guide to include a recommendation for assessment and referral to a healthcare provider specializing in disability management, if needed.

Published in January under the direction of the ADA, the “Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes — 2024” outlines what should be included in diabetes care, treatment guidelines, goals and evaluation tools.

Verduzco-Gutierrez was part of this year’s American Diabetes Association Professional Practice Committee, a group of about 40 medical professionals of various specialties. The committee reviews and updates the guidelines used by healthcare professionals across the country in the treatment of diabetes.

She said this was the first time the diabetes guide considered disabilities in its recommendations.

Under the disability section of the guide, it recommends that a patient with diabetes be assessed for disability at each medical visit. If a disability is impacting their ability to function or properly manage their diabetes, they should be referred to a professional specializing in that disability.

According to the ADA guide, a disability is a “physical or mental impairment that substantially limits one or more major life activities of an individual.” It further states diabetes can cause a 50-80% increased risk of disability compared to those without diabetes. Lower-body functionality is the most common diabetes-related disability.

“The recommendation is to screen patients who have diabetes for disabilities because a lot of them do end up getting neuropathy and losing legs, having strokes, getting amputations. Helping write the guidelines for all clinicians to follow when it comes to taking care of diabetic patients, that’s huge,” Verduzco-Guiterrez said.

She said this work was especially meaningful in a city like San Antonio, which has a large population of people living with diabetes and diabetes-related complications.

“We have a lot of patients who use a prosthetic. There are so many patients that do get amputations and we need to help with their disability and mobility issues,” she said.

In the guide, it is recommended that clinicians also consider social determinants of health, race/ethnicity and socioeconomic status. Rates of diabetes-related major amputations are found to be higher among members of racial or ethnic minority groups and those who live in rural or underprivileged areas.

Verduzco-Guiterrez was one of two physical medicine and rehabilitation professionals on the ADA guide committee.

 

The 2024 ADA guide can be found in the January 2024 Diabetes Care Journal:

https://diabetesjournals.org/care/article/47/Supplement_1/S52/153956/4-Comprehensive-Medical-Evaluation-and-Assessment

 

The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is one of the country’s leading health science universities and is designated as a Hispanic-Serving Institution by the U.S. Department of Education. With missions of teaching, research, patient care and community engagement, its schools of medicine, nursing, dentistry, health professions, graduate biomedical sciences and public health have graduated more than 42,550 alumni who are leading change, advancing their fields and renewing hope for patients and their families throughout South Texas and the world. To learn about the many ways “We make lives better®,” visit UTHealthSA.org. Stay connected with The University of Texas Health Science at San Antonio on Facebook, Twitter, LinkedIn, Instagram and YouTube.

Study: Higher chemical concentrations found in baby teeth of children with autism

Tooth, dental implants
Baby teeth were studied to discover possible connections between chemicals and autism spectrum disorder.

A recent exploratory study by a researcher at The University of Texas Health Science Center at San Antonio found a potential link between a buildup of organic chemicals in baby teeth and autism spectrum disorder (ASD).

In a study published March 14, in the Journal of Xenobiotics, Raymond Palmer, PhD, a biostatistician and epidemiologist with the department of family and community medicine at UT Health Science Center San Antonio, investigated whether children with ASD had a higher concentration of organic chemicals in their baby teeth compared to teeth from children without ASD.

Autism spectrum disorder is a neurodevelopmental disorder affecting between one in every 30 to one in every 44 births in the United States and is the most diagnosed childhood developmental disorder. Idiopathic ASD is believed to arise from interactions with genes and environmental factors.

Getting to the root of it

To investigate the potential concentrations of chemicals in children’s teeth, Palmer and his team pulled from a repository of hundreds of donated teeth, mostly from the Interactive Autism Network. The IAN is the world’s largest online autism research forum with more than 43,000 participating families. Researchers took a random sample of 42 teeth with 22 from children with ASD and 20 from children without ASD.

Baby teeth contain a record of toxic exposure that occurred in utero. Tooth dentine and enamel start to form in the womb around the second trimester. Whatever the mother is exposed to during that time is absorbed into the developing enamel and is sequestered there indefinitely.

Palmer

“The mother’s exposures are what the developing fetus is exposed to,” Palmer said. This would mean that the mother of the child was exposed to these chemicals either from breathing them in the air, ingesting them in food or absorbing chemicals through their skin.

The sampled teeth were crushed to atoms and analyzed using gas chromatography and mass spectrometry. Over 11,000 chemicals were discovered among the teeth with an average of 315 chemical compounds per tooth. About 200 of these chemicals were identified through the Chemical Abstract Services libraries. CAS is a division of the American Chemical Society and their database contains millions of registered substances and is known as the “gold standard” for chemical substance information.

Higher chemical concentrations found in teeth of children with ASD

The results showed there was a significantly higher concentration of chemicals in the teeth of children with ASD compared to children without ASD. Most of the chemicals found were phthalates, plasticizers, pesticides, antimicrobials and solvents used to produce these compounds. Five chemicals found are listed on the Pesticide Action Network’s “Bad Actors” list. PAN is an organization that aims to highlight the potential harm of industrial agriculture and work toward finding alternatives to harmful pesticides. Many of the chemicals found in this study are fragrance additives for personal care or cleaning products and food additives.

Palmer said it is unclear why there is a higher concentration of chemicals in the teeth of children with ASD, but it could mean these individuals have a decreased ability to metabolize these chemicals.

“There are always environmental interactions with your genetics and that is highly individual. Some people could be exposed to these chemicals and metabolize them just fine, but others just cannot. Over time it wreaks havoc on your neurons,” Palmer said.

No ‘silver bullet’ to causes of autism spectrum disorder

Palmer said pinpointing the origins of ASD development is difficult because there are hundreds, possibly thousands, of genes connected to the development of ASD and thousands of environmental factors interacting with these genes.

“We’ve come out of the age of the ‘silver bullet.’ It’s not that way anymore. There’s not going to be any one thing that causes autism. It is basically a soup of interacting environmental toxins and our individual genetic makeup

. It is not nature or nurture – it is always both,” Palmer said.

 

Decrease chemical exposure whenever possible

Palmer suggests everyone should aim to decrease their exposure to potentially toxic chemicals, especially individuals who are pregnant or are trying to get pregnant. Ways to accomplish this include eliminating processed foods, avoiding unnecessary fragrances in personal care or cleaning supplies, removing carpets and using only low-volatile organic compound (VOC) paints.

Still, Palmer said, even the most conscientious person cannot avoid all chemicals in this modern life. He said real momentum will have to come through stronger public health protections to limit human exposure to potentially harmful chemicals.

“We need public policy to ensure we all have clean air, food and water,” he said.

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An Exploratory Investigation of Organic Chemicals Detected in Baby Teeth: Differences in Children with and without Autism

Raymond Palmer

First published: Journal of Xenobiotics, 2024, https://www.mdpi.com/2039-4713/14/1/25

 

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The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is one of the

country’s leading health science universities and is designated as a Hispanic-Serving Institution by the

U.S. Department of Education. With missions of teaching, research, patient care and community

engagement, its schools of medicine, nursing, dentistry, health professions, graduate biomedical

sciences and public health have graduated more than 42,550 alumni who are leading change, advancing their fields and renewing hope for patients and their families throughout South Texas and the world.

To learn about the many ways “We make lives better®,” visit UTHealthSA.org.

Stay connected with The University of Texas Health Science at San Antonio on Facebook, Twitter, LinkedIn, Instagram and YouTube.