Stem Cells and Regenerative Medicine Public Education Day is Dec. 2

WHAT:

The University of Texas Health Science Center at San Antonio has partnered with the World Stem Cell Summit to offer the Stem Cells and Regenerative Medicine Public Education Day on Tuesday, Dec. 2. This informational event, free and open to the public, immediately precedes the 2014 World Stem Cell Summit convening Dec. 3-5 in San Antonio.

The Health Science Center is an organizing sponsor of the World Stem Cell Summit, which is the largest interdisciplinary stem cell meeting. William L. Henrich, M.D., MACP, president of the Health Science Center, is a summit co-chair. The Public Education Day, an educational service for the city and region, includes a morning special public lecture and three afternoon expert panels with question-and-answer times.

WHEN:

Tuesday, Dec. 2. The 9 a.m. special public lecture, “Stem Cells: Their Biology and Promise for Regenerative Medicine,” will be delivered by Elaine Fuchs, Ph.D., HHMI Investigator and the Rebecca C. Lancefield Professor at The Rockefeller University in New York. Afternoon sessions starting at 1 p.m. will include Stem Cells 101, Health Care Applications and Hot Topics.

WHERE:

Pestana Lecture Hall and Holly Auditorium on the UT Health Science Center at San Antonio’s Long Campus, 7703 Floyd Curl Drive, San Antonio, TX 78229

WHO:

Elaine Fuchs, Ph.D., of The Rockefeller University delivers the special public lecture at 9 a.m. in the Pestana Lecture Hall. The afternoon sessions from 1 to 4 p.m. will be in the Holly Auditorium. Moderators, speakers and panelists in the afternoon sessions are from the UT Health Science Center at San Antonio, The University of Texas at San Antonio, Texas Biomedical Research Institute, U.S. Army Institute of Surgical Research, South Texas Veterans Health Care System, Texans for Stem Cell Research, BioBridge Global, INCELL Corp. and Baylor College of Medicine.

NOTES:

In Session 1 of the afternoon, “Stem Cells 101,” speakers will answer questions such as “What are stem cells?” and “What can we do with them?” The expert panel will also discuss ethical questions surrounding stem cells.

In Session 2, “Health Care Applications,” speakers will discuss how stem cells are being used in the study of neurological disease and trauma and burn wounds. Panelists will address stem cell and marrow donation, as well as the safety of clinical trials and the potential danger in seeking unproven treatments overseas.

In Session 3, “Hot Topics,” speakers will discuss emerging technologies to treat diabetes and brain disorders such as stroke and Parkinson’s disease.

Information and interactive booths including microscopes will be available in the afternoon. Please visit the Public Education Day website for more details: www.uthscsa.edu/op/stemcell.asp

 

The University of Texas Health Science Center at San Antonio, one of the country’s leading health sciences universities, ranks in the top 13 percent of academic institutions receiving National Institutes of Health (NIH) funding. The university’s schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced more than 31,000 graduates. The $787.7 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg. For more information on the many ways “We make lives better®,” visit www.uthscsa.edu.

CPRIT gives almost $4 million for CTRC-led research

SAN ANTONIO (November 20, 2014) — Two Cancer Therapy & Research Center scientists are leaders on $3.99 million in grants from the Cancer Prevention Research Institute of Texas that will help them develop next-generation breast cancer treatment drugs.

Rong Li, Ph.D., professor of molecular medicine, is principal investigator on a proposal that will both harness an existing drug for hot flashes that has potential anti-tumor activity, and create other agents that will help it work with greater precision.

“It balances feasibility and innovation,” Dr. Li said.

Ratna Vadlamudi, Ph.D., professor of obstetrics and gynecology, is leading a proposal to develop an innovative breast cancer drug that potentially could prevent the development of drug resistance in breast cancers.

“This funding will help us develop these first-in-class cancer therapy drugs that address the critical need of targeting therapy resistance and metastasis of breast cancer,” Dr. Vadlamudi said.

“Huzzah!” said Ian M. Thompson Jr., M.D., CTRC director. “This is a tangible confirmation of the exceptional merit of the science and clinical care provided by our CTRC scientists and physicians.”

Also collaborating on the two grants are scientists from the University of Texas at San Antonio — through the two institutions’ shared Center for Innovation in Drug Discovery — and UT Southwestern Medical Center and The University of Texas at Dallas.

In Dr. Li’s work, two different receptors drive estrogen activity – Estrogen Receptor alpha and Estrogen Receptor beta. Much more is known about ER alpha, while Dr. Li calls ER beta the “Cinderella sister.”

“It has a lot of similar characteristics, but in many cases it behaves in the opposite manner,” he said. “And in many cases – unlike ER alpha – it inhibits tumor growth.”

Because ER beta is present in as many as half of all breast cancer cases, scientists want to tap its tumor-suppressing activity.

A drug being developed by pharmaceutical company Ausio to treat menopause-related symptoms has already been tested enough to be proven clinically safe. One of its characteristics happens to be that it turns on the ER beta switch. Through an agreement with Ausio, the CTRC will be able to test this drug in combination with agents being developed at the Health Science Center.

“The novel part of this work is that we’ve discovered how to turn on the ER beta function – and also how to inhibit the process that turns it off,” Dr. Li said. “This proposal seeks synergy among these three approaches that might maximize the anti-tumor activity of ER beta.”

Dr. Vadlamudi’s proposal focuses on the mechanisms in treatment-resistant cells. The majority of breast cancers grow in response to the hormone estrogen, and therapies involve treating them with antiestrogens or aromatase inhibitors. But many patients, after an initial response, develop resistance to these drugs. Their tumors will mutate or modify an estrogen receptor (ESR1) and continue to develop by ESR1-driven pathways.

Dr. Vadlamudi and his team have designed a small-molecule drug called ECBI (ESR1 coregulator binding inhibitor) that has the potential to block multiple oncogenic pathways that occur in resistant cells, in that way preventing the development of drug resistance. The ECBI also potentially has fewer side effects and could delay the need to begin chemotherapy treatments that are much harder on the patient.

The CPRIT grant will allow researchers to take the next steps in the laboratory necessary to get the drug ready for clinical trials in patients. Both grants are early translational research awards.

Dr. Vadlamudi’s team includes Rajeshwar Rao Tekmal, PhD, of the Health Science Center, Ganesh Raj, M.D., PhD, of UT Southwestern Medical Center, and Jung Mo Ahn, PhD, of The University of Texas at Dallas.

Co-principal investigator on Dr. Li’s grant is Stanton McHardy, Ph.D., co-principal investigator and medicinal chemistry core director at the Center for Innovation in Drug Discovery, a collaboration of the Health Science Center and the University of Texas at San Antonio, and associate professor of chemistry at the University of Texas at San Antonio. Also working on the proposal are Steven Weitman, M.D., Ph.D., director of the Institute for Drug Development at the CTRC; John Kuhn, PharmD, professor of translational oncology at the UT College of Pharmacy and the UT Health Science Center and senior research director for the CTRC’s Institute of Drug Development; Matthew Hart, Ph.D., the CIDD high-throughput screening director from the UT Health Science Center; and Richard Elledge, M.D., CTRC oncologist.

 

The University of Texas Health Science Center at San Antonio, one of the country’s leading health sciences universities, ranks in the top 13 percent of academic institutions receiving National Institutes of Health (NIH) funding. The university’s schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced more than 31,000 graduates. The $787.7 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg. For more information on the many ways “We make lives better®,” visit www.uthscsa.edu.

James L. Holly, M.D., School of Medicine alumnus from Beaumont, receives national primary care award tonight in Washington, D.C.

SAN ANTONIO (Nov. 12, 2014) — James Larry Holly, M.D., a Beaumont family physician and CEO of Southeast Texas Medical Associates (SETMA, www.setma.com), will receive the inaugural Patient-Centered Medical Home Practice Award tonight in Washington, D.C., from the Patient-Centered Primary Care Collaborative. Dr. Holly is an alumnus of the School of Medicine at The University of Texas Health Science Center at San Antonio, where he served as president of the School of Medicine Alumni Association for five years and was recognized as Distinguished Alumnus in 2012.

“Larry Holly is a personal friend of mine and a faithful friend and alumnus of the School of Medicine, and his support is helping countless numbers of our students,” said William L. Henrich, M.D., MACP, president of the Health Science Center. “He regularly brings his vision for primary care and student education to our campus. We join him in celebrating this significant and well-deserved award.”

A patient-centered medical home is a model or philosophy of patient care that is patient-centered, comprehensive, team-based, coordinated, accessible, and focused on quality and safety. Marci Nielsen, Ph.D., M.P.H., CEO of the Patient-Centered Primary Care Collaborative, said the award recognizes a primary care practice that serves as a model for medical home transformation through innovation in practice design, partnership with patients in quality improvement and exemplary leadership in promoting the practice of team-based primary care. The Board of Directors of the Collaborative specifically cited, among other qualities, Dr. Holly’s genuine concern and focus on patients and families and the role they play in practice transformation.

“At the end of the day, it is leaders such as Dr. Holly who change the way medicine is practiced,” said Francisco González-Scarano, M.D., dean of the School of Medicine and vice president for medical affairs, UT Health Science Center. “They inspire with their vision and model the way with their practices.”

“Larry Holly is an inspiration to many of us who practice family medicine and primary care,” said Carlos Roberto Jaén, M.D., Ph.D., FAAFP, professor and chairman of the Department of Family and Community Medicine in the School of Medicine, UT Health Science Center. “His leadership of the highly successful SETMA, his advocacy of the concept of a patient-centered medical home, his embracing of technology to create practice efficiencies, his inclusion of patients in improving his practice operations, and his support of medical education and training for the next generation of primary care physicians are impeccable qualities to emulate. We are so fortunate to count him among our School of Medicine alumni.”

Dr. Jaén occupies the Dr. and Mrs. James L. Holly Professorship in the School of Medicine and sees patients in the school’s clinical practice, UT Medicine San Antonio.

Register early for Saturday’s Turkey Trot 5K Fun Run/Walk

SAN ANTONIO (Nov. 17, 2014) ― Looking to get trim and fit over the upcoming holidays ― or at least avoid gaining weight? Start out the holiday season Saturday, Nov. 22, at the School of Nursing Alumni Association’s annual Turkey Trot. The 5K fun run/walk will be held on the UT Health Science Center San Antonio track.

And while you are there, get a better understanding of your health by taking advantage of glucose, cholesterol and blood pressure screenings provided by Health Science Center nursing students.

Lark Ford, M.A., M.S.N., RN, clinical assistant professor in the School of Nursing, will be available to discuss healthy eating and exercise options to relieve stress during the holidays.

The run/walk is for all ages and levels of walkers and runners. The entry fee is $25 prior to race day, $20 for School of Nursing Alumni Association members and $30 on the day of the race. Register online at http://makelivesbetter.uthscsa.edu/sonturkeytrot.

The event will feature giveaways, prizes, refreshments and games, and will benefit the alumni association.

Canned goods will be accepted to donate to the San Antonio Food Bank.

Participants should enter the campus at 7703 Floyd Curl Drive near Medical Drive. The guard will direct you to the track and parking area.

 

The University of Texas Health Science Center at San Antonio, one of the country’s leading health sciences universities, ranks in the top 13 percent of academic institutions receiving National Institutes of Health (NIH) funding. The university’s schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced more than 31,000 graduates. The $787.7 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg. For more information on the many ways “We make lives better®,” visit www.uthscsa.edu.

Palacios students learn about health professions at UT Health Science Center San Antonio

SAN ANTONIO (Nov. 14) ― Thirty-one Palacios High School students attended the 2014 Health Professions Fair & Science Expo Nov. 8, where they learned how to insert a breathing tube in a medical training manikin, start an intravenous line and transfer a patient into a wheelchair, plus many other hands-on activities.

Sponsored and held at The University of Texas Health Science Center at San Antonio, the PHS students were among 1,500 from San Antonio and South Texas to attend the Science Expo. The event was designed to give high school and undergraduate college students the opportunity to explore a wide range of medical, dental and allied health careers.

Trull Foundation grant funds students’ science exploration

The students are members of the Scrubs Club, a health careers group begun this fall in Palacios, thanks to a two-year grant from the Trull Foundation of Palacios.

The grant funds a collaboration between the UT Health Science Center’s Office of Recruitment and Science Outreach, which organized the Science Expo, and the Palacios Independent School District.

Palacios science teachers Heidi Turner and Chris Page were sponsors for the trip, and Amy Morales, an English teacher and parent of one of the students, also accompanied the students to San Antonio.

“This was a great opportunity to allow the students to see something completely different from our facilities at home. We have a lot of students interested in health science careers,” Page said.

Turner, who coordinates the Scrubs Club, agreed. “I had 120 applications for the Scrubs Club and we accepted 47. From those, we took 31 students on this trip,” she said.

Student Victoria Carrizales, who attended the Science Expo, said, “I liked the hands-on activities. We identified the parts of the brain. I’m interested because my aunt is a radiologist in Port Lavaca.”

Sophomore Elizabeth Morales added, “I liked the fact that I could learn to put an IV in an arm.”

Morales wants to be a CRNA ― a certified registered nurse anesthetist ― said her mother, Amy Morales, a teacher who helped chaperone the trip and drove the bus to San Antonio. “Elizabeth has been very focused on this since the seventh grade.

“We’re a small school, but luckily we are blessed with groups like the Scrubs Club. We have community support that helps sponsor our programs and we are grateful, because without them we wouldn’t be here at this event,” Amy Morales added.

Scrubs Club

In addition to funding the trip to the Science Expo, the Trull Foundation grant is supporting the monthly after-school Scrubs Club meetings. The extracurricular group for Palacios junior high and high school students is designed to develop an appreciation for science and career opportunities in the health professions. The program also encourages the students to organize community events, such as blood drives and fundraisers for health-related associations, such as the American Diabetes Association.

The club meetings will feature a curriculum and health exploration kits developed by Irene Chapa, Ph.D., director of the UT Health Science Center Office of Recruitment and Science Outreach, plus presentations from local health professionals who will discuss their careers and become mentors to the students.

“The idea is to introduce students to various health topics and careers, and help them understand through hands-on activities what is involved in each career so they can decide if they want to pursue it,” Dr. Chapa said.

Science Exploration kits bring science to life

“The health exploration kits are a great way to help make science come alive,” Dr. Chapa said. “They allow science teachers to take the topics they are teaching in the classroom and make them more realistic through hands-on activities. For example, the ‘Exploring Medicine and the Cardiovascular System Kit’ contains stethoscopes, digital blood pressure monitors, a heart model, a portal electrocardiogram machine and sound cards with recorded heart sounds. Students will be able to hear what a normal heartbeat and a heart murmur sound like. They learn about the anatomy and physiology of the heart, cardiac pathology and cardiology-focused careers.”

Dr. Chapa has developed similar kits for science teachers in the Rio Grande Valley and Laredo area to check out and use in their classrooms.

Enriching science education in rural communities

Gail Purvis, executive director of the Trull Foundation said, “Living in rural Texas, our kids don’t usually have the opportunity to do these types of activities. What we are trying to do is to expand the students’ awareness of all of the different health careers.”

According to Purvis, due to a large immigrant population and many residents earning a living with seasonal occupations such as fishing and agriculture, 43 percent of Palacios residents have not graduated from high school or earned a GED. The science curriculum, mentoring and hands-on activities can open students’ eyes to educational and career opportunities they may not have considered.

“We have a small hospital here with a primary care physician, a nurse practitioner, and lab and X-ray facilities,” explained Purvis, who also serves on the Palacios Community Hospital Board. “I became involved with the hospital board because we wanted to maintain local health care for our community to make sure we have 24-hour medical care available. Our hospital plays a critical role by stabilizing and providing care, and transporting serious cases to Matagorda Regional Medical Center 30 minutes away.

“Sometimes we have a difficult time recruiting health care staff with experience,” she explained. “That’s another reason the Trull Foundation is interested in seeing that our students are exposed to the health professions. We want them to come back and practice in rural Texas.”

Dr. Chapa added, “We have been coordinating the Health Professions Fair & Science Expo for 12 years. Our office facilitates student visits to our campus, as well as volunteering and mentoring opportunities. We also have summer research internships for high school students and undergraduate college students who are interested in health careers. We are looking forward to a close relationship with Palacios ISD and appreciate the funding the Trull Foundation is providing to support this.”

Walk and Talk with Health Care Professionals this Saturday at Woodlawn Lake Park

WHAT:

Salud al Pasito, Small Steps Toward Better Health, where the public can take a life-changing stroll with health care professionals and students

WHEN:

Saturday, 10 a.m. health fair; 10:50 a.m. guest speaker; 11 a.m. walk starts

WHERE:

Woodlawn Lake Park, 1103 Cincinnati Ave., San Antonio, TX 78201

NOTES:

Register at www.SaludalPasito.org or call 210-562-5565.

Free healthy snacks and drinks * Free health screenings * Free registration * Prize giveaways * Rain or shine

Special thanks to the School of Medicine, Center for Medical Humanities & Ethics, and School of Nursing Student Health Center at the UT Health Science Center, the South Central Area Health Education Center and H-E-B. Endorsed by the Mayor’s Fitness Council.

 

The University of Texas Health Science Center at San Antonio, one of the country’s leading health sciences universities, ranks in the top 13 percent of academic institutions receiving National Institutes of Health (NIH) funding. The university’s schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced more than 31,000 graduates. The $787.7 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg. For more information on the many ways “We make lives better®,” visit www.uthscsa.edu.