TIME magazine highlights UTHSC research on ADHD

Timemag_BODYSan Antonio (Dec. 3, 2003) – The cover story in the Nov. 3 issue of TIME magazine, “Medicating Young Minds,” discusses the benefits and risks of medicating children with mood and behavior problems. The article highlights the current research in this area being conducted by scientists around the nation – including Steven Pliszka, M.D., chief of child psychiatry at The University of Texas Health Science Center at San Antonio.

The article explains that Dr. Pliszka conducted brain scans of children with attention-deficit/hyperactivity disorder (ADHD) who were untreated, as well as children who had been medicated for at least a year, and then compared the brain scans of these two groups. According to TIME, “The treated group showed no signs of any deficits in brain function as measured in blood flow.”

In his research, Dr. Pliszka uses technology called functional magnetic resonance imaging (fMRI) to take active pictures of the brain. His groundbreaking ADHD studies are aimed at determining the cause of this mysterious disorder, which has baffled both parents and doctors for years. In 2002, Dr. Pliszka received an $870,000 grant from the National Institutes of Health to advance his research.

Portable blood analyzer picks up cases of anemia in Mexican children

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One of the children at Casa Hogar Douglas in Nuevo Laredo.

San Antonio (Dec. 3, 2003) – A portable blood analyzer developed at The University of Texas  Health Science Center at San Antonio (UTHSC) and commercialized by AVOX Systems of San  Antonio helped diagnose a young child with anemia recently during a visit to a children’s home  in Nuevo Laredo, Mexico. The device, called an oximeter, also found anemia in two children in  the same home last year.

A church-sponsored team including three pediatricians and several registered nurses and  licensed vocational nurses brought the oximeter and other equipment to the Casa Hogar  Douglas children’s home in Nuevo Laredo on Oct. 18. Blood, urine and vision screenings were  performed. “We’ve been visiting this home for about eight years,” said Yolanda Medina, a nurse practitioner employed by the UTHSC department of pediatrics/division of neonatology. “For the last two years, Dr. Pete Shepherd has been kind enough to lend us the oximeter, which has been very helpful. Last year we had two to three people with anemia, this year just one young girl. When we first started visiting, more than half the children were anemic.” Dr. Shepherd is professor of physiology at the UTHSC and president of AVOX Systems.

The group also conducts classes in first-aid, dental care and the physical changes that occur during childhood. The results are impressive. “Every year the children are healthier and need less treatment,” Medina said. “We leave behind medications with dosage information to the directors of the home and for the Mexican doctor who visits the home on a monthly basis.”

The team members set up seven stations to check weight, measurement, urine and blood. The 4-pound oximeter measures total hemoglobin and other blood values. “The blood station is the one the children fear the most but it also is the one that interests them the most,” Medina said. “We give the children pencils and stickers to offset the fear.”

Youngsters ages 4 to 17 live at the children’s home. Some are orphans, while others have parents who can’t take care of them. The group, which included nurses from University Hospital and Methodist Hospital, will make another trip next October. The South Texas Center for Pediatric Care also donated medications and equipment.

UTHSC to co-sponsor conference on Cancer-Induced Bone Diseases

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Mundy

San Antonio (Dec. 2, 2003) – At least 300 of the world’s best-known researchers in the field of  bone metastasis and myeloma are expected to attend the IVth International Conference on  Cancer-Induced Bone Diseases Dec. 7-9 in San Antonio, Texas.

A video welcome from U.S. Sen. Kay Bailey Hutchison of Texas will kick off the conference,  which is sponsored by The Paget Foundation for Paget’s Disease of Bone and Related Disorders,  The University of Texas Health Science Center at San Antonio and the National Cancer Institute.  Sen. Hutchison in 2001 spearheaded the passage of the Hematological Cancer Research Investment and Education Act, which authorized $25 million to expand public education, outreach and early detection programs for three deadly blood cancers, leukemia, lymphoma and multiple myeloma.

“The purpose of the meeting is to present clinicians and basic scientists from all over the world with many of the extremely exciting research discoveries that have occurred since the last symposium was held in 2002,” said Conference Chairman Gregory R. Mundy, M.D., professor of medicine at The University of Texas Health Science Center at San Antonio. These discoveries include:

• The central role of host cells in the bone microenvironment, their effects on tumor cell phenotype, and their potential as therapeutic targets;
• New pharmacologic and surgical approaches directed specifically to bone metastasis;
• Direct effects of bisphosphonates on tumor cells;
• Pathophysiology of osteoblastic metastasis;
• Bisphosphonates as adjuvant therapy in breast cancer;
• The role of proteasome inhibition in myeloma bone disease; and
• New bone markers and their potential for monitoring cancer-induced bone disease.

The conference also will explore future directions, including new approaches to the treatment of bone cancer pain, the further development and improvement of bone imaging techniques, and developments in orthopedic approaches to bone metastases and their complications. Important issues such as the cost-effectiveness of new therapeutic approaches will be discussed.

Note to media: The following abstracts are deemed particularly newsworthy and are available on request. They are embargoed until the dates and times of their presentation

“Gene Sets Driving Tissue-Specific Breast Cancer Metastasis,” lead author: Joan Massagué, Ph.D., Memorial Sloan-Kettering Cancer Center;

“Osteopontin and Bone Metastasis,” lead author: Ann F. Chambers, Ph.D., University of Western Ontario;

“Proteasomes and Host Defense Against Cancer: From New Insights to Novel Therapies,” lead author: Alfred L. Goldberg, Ph.D., Harvard Medical School;

“Role of Matrix Metalloproteinases in Bone Remodeling and Malignant Progression,” lead author: Zena Werb, Ph.D., University of California at San Francisco;

“Clodronate Adjuvant Therapy for Operable Breast Cancer,” lead author: Trevor J. Powles, M.D., Royal Marsden Hospital, London, England; and

“Detection of Skeletal Metastases in Breast Cancer Using a Novel Biochemical Marker of Bone Resorption (ALPHA CrossLaps),” lead author: Claus Christiansen, M.D., Center for Clinical and Basic Research, Ballerup, Denmark.

A complete listing of conference dates, speakers and topics is available online atwww.paget.org/intl_conference.pdf.

State leaders ensure additional $9 million for RAHC

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Gov. Perry announces that line-item vetoes in the state budget freed up $9 million that will be used to fund RAHC operating costs.

San Antonio (Dec. 2, 2003) – Gov. Rick Perry and Lt. Gov. David Dewhurst visited the Medical  Education Division of the Regional Academic Health Center on Nov. 18 to make a most-  welcome announcement just before the holidays – namely that line-item vetoes in the state  budget had freed up an additional $9 million to fund RAHC operating costs.

The leaders met a warm reception in Harlingen from Dr. Francisco G. Cigarroa, Health Science  Center president, and Lower Rio Grande Valley lawmakers including Senators Eddie Lucio Jr.  and Juan Hinojosa. President Cigarroa said the funding, which doubles the $9 million already  appropriated for the RAHC this biennium, will help continue the programs of the Medical  Education Division, located at Harlingen, and will enable the Health Science Center to  continue to make preparations for the RAHC Medical Research Division to open in 2004 at  Edinburg. The Health Science Center is responsible for operating the RAHC’s Harlingen and Edinburg divisions.

“Funding for the Regional Academic Health Center will play a vital role in treating, healing and improving the lives of people along the Texas-Mexico border,” Gov. Perry said. “The RAHC mission of training the future doctors and medical professionals of the Rio Grande Valley is critical to a healthier border and a healthier Texas.”

Lt. Gov. Dewhurst represented the Legislative Budget Board, which was to receive the formal request for the funding. He and Gov. Perry reached an agreement with House Speaker Tom Craddick for the additional RAHC appropriation.

“We are so grateful to Gov. Perry and Lt. Gov. Dewhurst for being with us today, for their support for the RAHC, and for bringing such welcome news,” Dr. Cigarroa said. “We are grateful to all our Valley delegation for their continued support, which ensures that the Regional Academic Health Center continues to be built on a solid foundation.”

Sen. Lucio, author of the 1997 legislation that established the center, was introduced as “the Father of the RAHC” by Harlingen Mayor Connie de la Garza. House sponsorship of the RAHC bill was accomplished by Sen. Hinojosa, then a representative. In an opinion editorial released Nov. 21, Sen. Lucio extended his “appreciation and gratitude to our state’s leadership on behalf of South Texas for their foresight in recognizing the need for this strategic investment in the area.”

10 tips for having a safe holiday season from your friends at UTHSC

San Antonio (Nov. 24, 2003) – Thanksgiving Day is almost here and Hanukkah, Kwanzaa, Christmas and New Year’s are just around the corner. Now is the time to review some safety concerns for children, pets and even all of us “more responsible” adults. Here are 10 precautions for staying safe this holiday season, according to experts from The University of Texas Health Science Center at San Antonio (UTHSC).

1. Don’t drink and drive. Michelle Price, director of UTHSC’s South Texas Injury Prevention and Research Center, notes that a new survey of more than 600 San Antonio residents found that 20 percent admitted they had driven while impaired by alcohol. Establish who will be the designated driver or take a taxi if you plan to drink at holiday parties, Price says.

2. Don’t worry needlessly about children eating your poinsettia plants. Dr. Miguel Fernández, medical director of the South Texas Poison Center at the UTHSC, says while poinsettias may cause a poison oak-like skin irritation and minor mouth or stomach upset, they are considered non-poisonous. If you have any questions or concerns about these plants or others, you might prevent an unnecessary visit to the emergency center by first calling the Poison Center at 1-800-222-1222. The call is free and available 24 hours a day, including holidays.

3. Keep medicines out of the reach of children since they may easily be confused with holiday candies. Common over-the-counter cold remedies may look like M&M’s when left out. Dr. Fernández says the Poison Center receives dozens of calls each month for this problem.

4. Toddlers may swallow the needles on your natural holiday tree. Dr. Juan Parra, pediatrician at the Health Science Center, says the needles can cause a severe reaction in a toddler’s airway. Pine needle aspiration won’t completely obstruct the airway, but it will be uncomfortable and may require removal by a scope used by a pulmonologist, Dr. Parra says. Be sure to get the freshest tree possible to minimize needle shedding.

5. Everything on the tree is open game for a toddler to put into his mouth. If a little one can reach it, he may try to eat it. In addition to needles, this includes the lights, icicles, ornaments and strings of popcorn. Also be vigilant when you leave out bowls of peanuts, candies and other holiday snack foods, even if they seem to be out of toddlers’ reach.

6. Small parts on toys or nativity sets may become lodged in the throat. Vicky Smith, department of emergency medical technology, says your response will depend on your child’s size. If the child is small enough to rest on your forearm (1 year old or younger), Smith recommends holding him upside down, giving five pushes to the back between the shoulder blades and five chest thrusts in the middle of the sternum. If the child is older, sit him on your lap and do five abdominal thrusts. “The important thing to stress is that if the child is coughing, leave him alone, because this means the child is breathing,” Smith said. “Doing the thrusts prematurely can cause the object to lodge deeper.”

7. Get enough sleep. Disruptions in one’s sleep at the holidays can have adverse effects on health and safety, says Dr. Paul Ingmundson, clinical professor of psychiatry. People experiencing sleep deprivation due to too many holiday social commitments may be vulnerable to the effects of sleep loss on increasing the risk for fatigue-related accidents, especially on those long holiday drives to visit friends and relatives.

8. Cook your turkey thoroughly. Take out the stuffing and refrigerate it promptly after serving to guard against Salmonella poisoning. Dr. Fernández says the signs of Salmonella poisoning include flu-like symptoms with nausea, crampy upset stomach and diarrhea. Symptoms can develop six to 48 hours after exposure and last up to a week. If this occurs, contact your primary care physician.

9. Keep dogs away from chocolate. Dr. Robert H. Wolf, director of laboratory animal resources at the UTHSC, says chocolate contains theobromine, a caffeine-like substance that dogs are unable to metabolize (break down). This stimulant can lead to excitement, seizures, coma and death, much like the drug known as “speed.” White chocolate contains very little theobromine, while darker, less sweetened chocolate (like baking chocolate) is much more potent and dangerous to a dog. “The smaller the dog and the darker the chocolate, the more concentrated and dangerous a given amount will be,” Dr. Wolf said.

10. Holiday stress can cause feelings of being overwhelmed, sad or depressed. Talk to someone about it, recommends Dr. Joseph Kobos, department of psychiatry. Limit your activities if you feel overwhelmed. While family connections are a source of sustenance and support for many people, there are occasions when family gatherings stimulate tension and conflict. Set limits for yourself.

STEER earns national award from Association of Physician Assistant Programs

Contact: Will Sansom
Phone: 210-567-2570
E-mail: sansom@uthscsa.edu

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Dr. J. Dennis Blessing (second from left) presents the APAP Partnership Award to STEER team members (L-R) Roger Perales, Dr. Claudia Miller and Joan Engelhardt. clear graphic Dr. J. Dennis Blessing (second from left) presents the APAP Partnership Award to STEER team members (L-R) Roger Perales, Dr. Claudia Miller and Joan Engelhardt.

San Antonio (Nov. 25, 2003) – The Association of Physician Assistant Programs (APAP) has  awarded the South Texas Environmental Education and Research (STEER) program with its  distinguished Partnership Award. The APAP bestows the award yearly on outstanding  educational programs whose efforts advance the APAP’s mission and physician assistant (PA)  education. The mission of the APAP is: 1. to foster faculty development; 2. to promote  excellence within PA programs; 3. to facilitate research and scholarly activities; 4. to advocate  for PA education; and 5. to maintain and advance the organization.

J. Dennis Blessing, Ph.D., P.A.C, associate professor and chair of the department of physician  assistant studies at The University of Texas Health Science Center at San Antonio (UTHSC), n   nominated STEER for the award.

“I have been involved with a number of educational projects over the years and none are as good  as STEER in helping educate our students in gaining an understanding of the public health  issues in a medically underserved geographic area,” Dr. Blessing said. “STEER is a valuable  partner in our efforts to meet the physical, social and mental needs of the Texas/Mexico border  region.”

Dr. Blessing said the STEER experience has opened students’ eyes to the realities of difficult health situations in the border region brought on by poverty, inadequate water supplies, poor waste management, inadequate medical insurance, poor air quality and a population with limited access to education and public support.

STEER was established in 1996 in Laredo as a part of the Health Science Center’s department of family and community medicine to provide residents, medical, nursing and public health students with a four-week elective on border health. Students from universities across the country can enroll in the course. Roger Perales, B.S., R.S, and Joan Engelhardt, B.S.N., R.N., M.S.Ed., are the environmental health coordinators for STEER. Claudia Miller, M.D., M.S., is the director.