Post-COVID study to enroll 900 in South Texas

Picture of Caregiver holding hand of patient

UT Health Science Center San Antonio, University Health, Laredo partners comprise the state’s only site selected for current phase of NIH initiative.

Media contacts: Will Sansom, UT Health San Antonio, (210) 567-2579,

Shelley Kofler, University Health, (512) 294-5224,

SAN ANTONIO (Oct. 28, 2021) — Researchers at The University of Texas Health Science Center at San Antonio, who see patients at University Health, are recruiting 900 adult COVID-19 survivors for a federally funded study that seeks to understand why some people have prolonged symptoms or develop new or returning symptoms after the acute phase of SARS-CoV-2 infection. The partnership also includes the Laredo Health Department as a clinical partner in this major effort.

RECOVER study logo NIHThe South Texas study is called “Prevention, Evaluation and Incidence of Long-Term COVID in South Texas” (PREVAIL South Texas) and is part of the National Institutes of Health (NIH) “Researching COVID to Enhance Recovery” (RECOVER) Initiative.

UT Health Science Center San Antonio, University Health and Laredo partners comprise the only Texas site in the RECOVER Initiative’s implementation phase and one of only 17 research hubs throughout the U.S. The health science center is projected to receive $15 million from NIH during up to four years of patient follow-up.

The most common lingering symptoms include pain, headaches, fatigue, “brain fog,” shortness of breath, anxiety, depression, fever, chronic cough and sleep problems.

Photo of Dr. Thomas Patterson
Thomas Patterson, MD

“How frequent is it? How long does it last? What makes it better? This study will answer a myriad of questions about the post-acute sequalae of SARS-CoV-2 infection (called PASC),” said PREVAIL South Texas Principal Investigator Thomas Patterson, MD, an infectious diseases specialist and professor of medicine in the health science center’s Joe R. and Teresa Lozano Long School of Medicine. He also leads COVID-19 infectious diseases care at University Health.

“We will reach out to community partners University Health and the Laredo Health Department to recruit survivors, especially in the Latinx population that has been so heavily and disproportionately impacted by COVID-19,” Dr. Patterson said. The University of Texas Education and Research Center at Laredo will be a host venue in the border city.

Delta variant’s role

In keeping with recent trends, PREVAIL South Texas will include a strong focus on assessing long COVID in those with the delta variant and in previously immunized individuals.

Concept art of coronavirus“Research is needed to address emerging questions such as, ‘What are the long-term consequences for people who have new variants like delta?’ and ‘What happens with people who develop COVID-19 infection despite prior vaccination?’” Dr. Patterson said. “We already know breakthrough infections aren’t that common, and vaccination dramatically reduces the risk of hospitalization and death.”

Investigators from many disciplines at the health science center and University Health will study how best to treat the broad spectrum of PASC that manifests in the most-affected patients and to prevent or limit symptom onset in others, Dr. Patterson said.

UT Health Science Center San Antonio, University Health and the Laredo partners are among the centers in the adult recovery study cohort. Children will be studied at other centers.

“We are proud to partner with UT Health San Antonio in this critically important study,” said Roberto Villarreal, MD, MPH, senior vice president of research and chief analytics officer with University Health. “We look forward to gaining new insight in delivering the best care for our patients and everyone affected by COVID-19 now and in the future.”

Learning the scope of the problem

The PREVAIL South Texas team will administer questionnaires to participants on a quarterly basis to document how they are feeling. From that starting point, other investigations will ensue.

Monica Verduzco-Gutierrez, MD
Monica Verduzco-Gutierrez, MD

“Groups of patients will undergo more intensive study depending on the symptoms they report,” said Monica Verduzco-Gutierrez, MD, chair of rehabilitation medicine at UT Health Science Center San Antonio, chief of rehabilitation medicine with University Health and PREVAIL South Texas co-investigator. “If fatigue is particularly important in a subset of people, those individuals will have specific tests to learn more about it. If the main issue is pain, the testing will be geared to that. Each line of testing will be different, depending on the primary symptom or cluster of symptoms the patient is having.”

Dr. Gutierrez has followed more than 400 recovered COVID-19 patients since 2020 in post-COVID clinics at University Hospital and the health science center’s Medical Arts and Research Center.

Brain fog and other neurological symptoms have been documented in patients who recovered from COVID-19. A small group of PREVAIL South Texas participants will have intensive workups including magnetic resonance imaging (MRI) and spinal taps to understand what causes these symptoms to develop or persist in some patients.

Health science center faculty seeing patients at University Health and the Laredo partners will also examine:

  • Social determinants, such as ethnicity and income, and how they might impact PASC and its persistence.
  • Psychological disorders induced by COVID-19 disease.
  • Metabolic issues and dysfunction of cellular power plants called mitochondria.
  • Organ injury, with emphasis on the heart, lung and kidney.

Springboard to further investigations

The RECOVER Initiative of NIH will follow participants and collect samples that then are used to support science that is funded outside the initiative, Dr. Patterson said.

ResearchMark Goldberg, MD, a neurologist who is assistant vice president for translational research at the health science center and sees University Health patients, is a PREVAIL South Texas co-principal investigator.

“Here, in the RECOVER Initiative, researchers will learn by observing a set of people, by following them closely over several years,” Dr. Goldberg said. “One of the important jobs is to be sure that the people we study in this nationwide initiative truly reflect the makeup of the country.”

The purpose of the RECOVER Initiative is to come up with ideas that will suggest interventional studies, Dr. Goldberg said. Investigators will not wait until the four-year follow-up period ends to start these studies. “As soon as we have data, scientists will start working,” he said. “Once we understand the scope of the problem, NIH wants interventional studies to follow closely behind the RECOVER Initiative, or maybe not even behind.”

Post-COVID recovery in Latinx families

Both Dr. Patterson and Dr. Goldberg said PREVAIL South Texas is uniquely poised to serve the Latinx population, including the border population in Laredo.

People raising arms graphic“We have a strong track record of community engagement for South Texas communities, so we know that we can get the message out about this important initiative,” Dr. Goldberg said.

“Patient input is key,” Dr. Patterson said. “It is very important to engage the community to make sure that this study of post-COVID recovery is done in a way that best addresses their needs. We are doing this for the families of our state.”

Barbara Taylor, MD

PREVAIL South Texas co-principal investigator Barbara Taylor, MD, MS, agreed. “We will be part of a national effort to rigorously define what sorts of consequences COVID-19 can have long term for all sorts of different people, including our South Texas population,” said Dr. Taylor, an infectious disease specialist who is associate professor of medicine and assistant dean for the MD/MPH program in the Long School of Medicine and infectious diseases clinician and researcher at University Health, as well.

“Hopefully we will pave the way not just for better understanding these post-COVID-19 sequalae, but also treatments, prevention and all the things that we want to do to reduce the impact of COVID-19 in our communities,” Dr. Taylor said.

Vaccination and benefit

One of today’s front-burner questions is whether COVID-19 vaccination protects recipients against long COVID, and one would hope that it does, Dr. Taylor said.

“We know that people who are vaccinated have less severe disease, and we definitely know that having more severe disease predisposes people to long COVID,” she said. “Hopefully there is a protective effect of the vaccines against the sequalae, but we do not know that yet, so we can’t promise it. We have to be as rigorous as possible before we jump to conclusions. This study is a step toward doing that.”

Who is being recruited

PREVAIL South Texas will recruit patients from the COVID-19 Outpatient Virtual Infectious Disease Clinic run by Dr. Taylor. “We will also recruit patients previously enrolled in our clinical trials of medications including remdesivir, some of whom will have post-acute sequalae of COVID-19,” Dr. Patterson said. “Others won’t, and we will make a comparison. And we will look at people who didn’t have COVID-19 at all as another comparison group.”

“The hope is that most people who recovered from COVID-19 are going to stay recovered,” Dr. Goldberg said. “But there’s going to be a set of people who have consequences months and years later, either because the problem wasn’t detected or maybe there are late complications of this disease.”

The RECOVER Initiative cohort studies, funded by NIH at nearly $470 million, are addressing a potentially massive, long-term public health problem. The U.S. Centers for Disease Control and Prevention data tracker in October reported that the nation had reached 45 million cases of COVID-19 since the pandemic began. Millions of other cases undoubtedly have gone untested and unreported.

“If there are 100 million people who have had COVID-19 nationwide, even if 5% get these complications, that’s a lot of people,” Dr. Goldberg said.

For more information about the PREVAIL South Texas study, call 210-567-5262 or visit RECOVER-TX.ORG.

This announcement is also posted at University Health news: Post-COVID study.

The University of Texas Health Science Center at San Antonio, also referred to as UT Health San Antonio, is one of the country’s leading health sciences universities and is designated as a Hispanic-Serving Institution by the U.S. Department of Education. With missions of teaching, research, patient care and community engagement, its schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have graduated 39,700 alumni who are leading change, advancing their fields, and renewing hope for patients and their families throughout South Texas and the world. To learn about the many ways “We make lives better®,” visit

Stay connected with The University of Texas Health Science Center at San Antonio on FacebookTwitterLinkedInInstagram and YouTube.

To see how we are battling COVID-19, read inspiring stories on Impact.

About University Health

University Health is San Antonio’s only locally owned health system and the only academic medical center in South Texas. Its University Hospital serves as the region’s Level I trauma center for adults and children, and is the only area hospital to be state-designated at the highest level for both its Maternity Center and Neonatal Intensive Care Unit. Outpatient care is provided through a comprehensive network of urgent, primary and specialty care centers. For more than 100 years, University Health has been committed to delivering compassionate, culturally competent and high-quality healthcare, based on a strong foundation of outcomes‐based research and innovative teaching. Learn more at Follow us on Twitter and Facebook.

Gain insight into effective treatments and health trends through our blog HealthFocusSA.



Share This Article!