New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the prestigious journal Nature. Researchers from the Long School of Medicine contributed to the study.
Ewing sarcoma is a bone and soft tissue cancer that primarily affects children and adolescents.
Study author Alexander Bishop, DPhil, with team members at the Greehey Children’s Cancer Research Institute, previously showed that one of the genetic code-reading machines is overactive in Ewing sarcoma. In the newly published study, they confirmed that, in Ewing sarcoma, this overactivity causes the nucleoli to break up into smaller entities.
“We are working now to better understand the impacts of this biology in Ewing sarcoma and how we can take advantage of it therapeutically,” Dr. Bishop said.