UT Health San Antonio to lead local COVID-19 treatment study at University Hospital

SAN ANTONIO (March 30, 2020) — Infectious disease physicians at UT Health San Antonio are among the first in the nation to test an investigational drug developed to treat the novel coronavirus.

Thomas Patterson, M.D., professor in the Long School of Medicine and chief of the Division of Infectious Disease at The University of Texas Health Science Center at San Antonio (UT Health San Antonio), is leading the study center that will enroll patients under care at University Hospital.

The first COVID-19 patient enrolled at University Hospital was on March 26, Dr. Patterson said.

The investigational drug, called remdesivir, is for adults 18 and older. The study is not open to members of the public as prevention of coronavirus infection. This study is reserved for hospitalized patients who are critically ill.

Worldwide, 440 patients are being sought for the study, which is being conducted at 75 study sites, located primarily in the U.S.

The purpose of the trial is to compare the safety and effectiveness of remdesivir with a placebo to establish the safety and effectiveness of this drug. “The study will evolve as we learn which agents work best. If remdesivir is safe and effective, then it will become the standard of care for the trial and new investigational drugs will be studied. There will be periodic monitoring points that will allow us to stop treatment with drugs that aren’t as effective and start testing new therapies as they are developed,” Dr. Patterson said.

According to the National Institute of Allergy and Infectious Diseases, which is sponsoring the trial, remdesivir has shown promise in laboratory and animal tests against COVID-19 and several other related viruses. It works by stopping an early mechanism the virus uses to reproduce. The drug has been tested in humans with Ebola. It also has been tested in animals in studies of the Middle Eastern respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), which are caused by other coronaviruses.

“This was an incredible team effort. Research leaders at UT Health San Antonio, including our Institutional Review Board, Clinical Trials Office, Clinical Translational Science Award group and Office of the Vice President for Research all collaborated quickly with University Health System, our clinical partner, for incredibly fast activation of this trial as soon as we learned we were a study site,” Dr. Patterson said.

“Our nurses and doctors are very encouraged to be able to offer this antiviral, which appears to be the most active to date against SAR-CoV-2, the virus causing COVID-19,” he said. “We anticipate that patients will be enthusiastic about participating.”

Brooke Army Medical Center is the only other San Antonio study site. Sites in Houston, Galveston and Dallas also are testing the drug in Texas.

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The Long School of Medicine at The University of Texas Health Science Center at San Antonio is named for Texas philanthropists Joe R. and Teresa Lozano Long. The school is the largest educator of physicians in South Texas, many of whom remain in San Antonio and the region to practice medicine. The school teaches more than 900 students and trains 800 residents each year. As a beacon of multicultural sensitivity, the school annually exceeds the national medical school average of Hispanic students enrolled. The school’s clinical practice is the largest multidisciplinary medical group in South Texas with 850 physicians in more than 100 specialties. The school has a highly productive research enterprise where world leaders in Alzheimer’s disease, diabetes, cancer, aging, heart disease, kidney disease and many other fields are translating molecular discoveries into new therapies. The Long School of Medicine is home to a National Cancer Institute-designated cancer center known for prolific clinical trials and drug development programs, as well as a world-renowned center for aging and related diseases.

The University of Texas Health Science Center at San Antonio, dba UT Health San Antonio, is one of the country’s leading health sciences universities and is designated as a Hispanic-Serving Institution by the U.S. Department of Education. With missions of teaching, research, patient care and community engagement, its schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have graduated more than 37,000 alumni who are leading change, advancing their fields and renewing hope for patients and their families throughout South Texas and the world. To learn about the many ways “We make lives better®,” visit www.uthscsa.edu.

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